Changes in clinical indicators in the treatment of patients with phlegmons of the maxillo-facial localization in case of the use of cryoconservated placenta extract

Abstract

The aim of our study was to establish how to use a standardized protocol for medical care for odontogenic phlegmons of maxillofacial localization, taking into account the biological rhythm of patients. Objects and methods. A total of 30 patients with odontogenic phlegmons of maxillofacial localization (2–3 cell spaces), aged 35 to 60 years, without systemic chronic diseases, regardless of gender, who underwent surgery in the form of opening and drainage of phlegmon with intravenous introduction of cryopreserved placenta. Results. Analyzing the dynamics of changes in the P-1.1 indicator, it should be emphasized that this indicator reached its maximum values for 1 day after surgery, which is probably due to the body’s response to iatrogenic trauma on the background of the inflammatory process. Analyzing the decrease of this indicator during the 3rd and 5th days, it should be noted that its significant value is observed in the period between the 3rd and 5th days closer to the 5th, on average by 1.78 ± 0.24. Analysis of the dynamics of the indicator P-1.2 gives grounds to show its uniform decrease during 1, 3 and 5 days after the operating period with normalization of the indicator for 7 days. The change in the dynamics of the P-1.3 indicator by its significant decrease on the 3rd day in 28% of cases and on the 5th day in 72% of cases with normalization of quantitative data on the 7th day is noteworthy. In the study of masticatory disorders (indicator P-4) should be noted the maximum value of this indicator on the 1st day, which is associated with known complications on the background of purulent inflammatory process and the presence of additional inflammatory process. A significant decrease in this indicator by 0.31 ± 0.09 points on the 5th day in 62% of cases with partial normalization on the 7th day in 62.3% and full normalization in 37.7% of cases is noteworthy. A similar picture was observed in the study of the dynamics of changes in P-1.5, but in contrast to the previous indicator, normalization on day 7 occurred in 82.9% of cases. In the study of indicators showing the dynamics of local changes deserves special attention indicator P-2.1, which on the 1st day after the operating period reached maximum values with a gradual decrease throughout the postoperative period, but the largest difference in its reduction by an average of 0.23 ± 00.9 scores were recorded on the 5th day in 56.9% of cases in patients with morning chronotype, operated on in the first half of the day. Conclusion. Based on the results of the study, we can say that the use of cryoextract of the placenta not only improves reparative function, but also reduces the recurrence rate in the postoperative phase and reduces the length of stay in medical institutions.