Фонд свободных аминокислот в резидентных лимфоцитах селезенки и печени: влияние ацетата свинца

Abstract

A comparative analysis amino acids fund of free in the lymphocytes of the spleen and liver after a single and course administration of lead acetate has been performed. The level of aspartate and tryptophan, as well as the total content of proteinogenic amino acids is increase in the lymphocytes isolated from the spleen of the animals exposed to acute lead intoxication. The levels of majority of the defined nonessential and essential amino acids as well as nitrogen-containing metabolites (phosphoethanolamine, citrulline, ethanolamine, ornithine and taurine) is increase in lymphocytes of the liver. BCAA level is increase in lymphocytes of the spleen in case of chronic lead intoxication. No significant changes in lymphocytes of the liver of animals exposed lead acetate chronic intoxication have been detected.