Характер функционально-метаболических нарушений и их коррекция у пациентов с диабетической полинейропатией

Abstract

The influence of intravenous laser irradiation of blood (ILIB) with nicergoline on the pain severity, the lactate and piruvate plasma level and ratio of them, pro-, antioxidant system, substance P and noradrenalin concentrations, vascular reactivity in patients with neuropathic pain (NP) due to diabetic polyneuropathy have been investigated. Visual analog scale and Neuropathy Symptom Score have been used to evaluate the pain. The patients of main group received basic therapy and ILIB by semi-conductor laser at X=0.67 ^m and radiation power at 3.0 mW with application time of 20 min and nicergoline. It has been established the reduction of NP in patients in main group was move evident than patients in control group. Combined treatment with ILIB led to the restriction of the lipid peroxidation reactions, the normalization of substance P concentration and the improvement of endothelium vasoregulation function in patients.