Эпидемиология инвазивной грибковой инфекции у детей с онкогематологическими заболеваниями, получающих иммуносупрессивную терапию

Abstract

Invasive fungal infections (IFI) are common infectious complications in patients with severe diseases who are in intensive care units and in hematological patients after transplantation of solid organs and hematopoietic stem cells. After analyzing the data of our Center (pediatric patients aged 0-18 years, n = 248) for the 4-year period, the following IFI pathogen structure was identified: 265 cases were in all, the vast majority were fungi of the Candida species — 74%, the Saccharomyces spp. — 5%, the majority of the moulds were the Aspergillus species — 8%, the Fusarium spp. — 4%, Zygomycetes class (Rhizopus, Mucor) — 4%, the Penicillium spp. — 3%, the Actinomyces spp. — 1%, the Cryptococcus spp. — 1%, the Geotrichum spp. — 1% and the Alternaria spp. (less than 1%) was isolated, as well. Two deaths of high-risk group patients because of fungal infections occurred during the 4-year period.