Влияние холестаза матери на печень двухсуточных крысят и коррекция патологии урсодезоксихолевой кислотой

Abstract

The purpose of research — to clarify the influence of maternal experimental cholestasis on liver development of a two-day offspring and the possibility to correct those violations by "Ursofalk". In this paper we used material from 30 inbred albino rats, histological, histochemical, morphometric and electronic microscopy methods of investigation. Under the influence of maternal cholestasis in the liver of two-day offspring the extention of sinusoid capillaries, in the cytoplasm of hepatocytes a reduction succinate dehydrogenase activity and increased activity of NADH — dehydrogenase was revealed. The development of significant ultrastructural disturbanses (lipid droplets disappear, increased heterogeneity of size and shape of mitochondria, increases number of lysosomes). Preparation "Ursofalk" partially restores the structure and metabolism of hepatocytes.