Изучение вариабельности ответа на препараты ацетилсалициловой кислоты у пациентов с ишемической болезнью сердца

Abstract

Selection of the optimal dose of aspirin (acetylsalicylic acid) is based on the idea that its antithrombotic effect is due to inhibition of platelet aggregation through the irreversible blockade in their COX-1 and almost complete suppression of the production of thromboxane A2. The term "variable response to aspirin", more accurately reflects the nature of the problem. The incidence of this condition varies from 10 to 45%, which is in itself contrary to the clinical results of the use of aspirin and depends strongly on the used methods for diagnosis of AR. It should be emphasized that the most common cause of AR - low compliance receiving ASA. It was shown that 29% of patients after myocardial infarction had AR, but 57% of them do not take aspirin on a regular basis. Moreover, only 60% of patients who were prescribed aspirin, taken the drug.