Использование водной и липосомной форм N-ацетилцистеина в эксперименте для коррекции изменений в легких, вызванных воздействием гипероксии

Abstract

Aerosolized N-acetylcysteine decreases the level of neutrophils in bronchoalveolar lavage fluid and the content of neutrophil elastase in lung tissue of newborn guinea pigs exposed to prolonged hyperoxia. The activity of alphal-proteinase inhibitor increases, probably due to the antioxidant effect of N-acetylcysteine and suppression of protein oxidative modification. The aqueous form of N-acetylcysteine seems to be more effective in decreasing lung inflammation and proteolytic injury.