Предсердный натрийуретический пептид у пациентов с ревматоидным артритом — маркер кардиоваскулярного риска

Abstract

We compared the prevalence of subclinical atherosclerosis by electron-beam computed tomography in patients with RA and 38 cardiovascular (CV) risk factors matched healthy controls without history of CV disease and evaluated its relation with traditional CV risk factors, inflammation and brain natriuretic peptide (BNP). The overall prevalence of coronary artery calcium (CAC) appeared to be higher in RA patients compared to controls. In the multiple regression analysis included classical CV risk factors age and hypertension appeared as independent factors predictive of presence of CAC. Disease Activity Score 28 and C-reactive protein (CRP) showed significant relationship with CAC presence. The levels of CRP and BNP were significantly associated with more extensive CAC (CAC>100). We suggested BNP as a useful biomarker for the early detection of atherosclerosis in RA.