The effect of Enrofloxacin and Ciprofloxacin on blood viscosity of ducks

Abstract

Fluoroquinolones are a group of dynamically developing synthetic antibacterial agents that are linked by a common mechanism of action, which consists in suppressing the key enzyme of a bacterial cell. The specificity of the mechanism of action determines the absence of cross-resistance to them in bacteria with antimicrobial agents of other chemical structures and determines their role in treatment of infections caused by resistant strains. A significant feature of fluoroquinolones is their pharmacokinetics, thanks to which a high degree of bioavailability is achieved in cases of their internal use. As a result of fluoroquinolones application in some cases there are some weakly expressed changes manifested in the form of anemia, thrombocytopenia, eosinophilia, increased erythrocyte sedimentation rate, leukocytopenia or leukocytosis. These adverse reactions raise the question of the influence of fluoroquinolones on the blood system. Studies of the influence of fluoroquinolones on blood viscosity parameters in chickens have shown that the use of Norfloxacin and Moxifloxacin does not significantly affect blood viscosity, without violating the physical and chemical properties of the internal environment of the body. In connection with the above mentioned purpose of work was to study the influence of Enrofloxacin and Ciprofloxacin on blood viscosity of ducks.