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dc.contributor.authorNesterkina, M. V.
dc.contributor.authorKravchenko, I. A.
dc.date.accessioned2020-12-01T09:07:18Z
dc.date.available2020-12-01T09:07:18Z
dc.date.issued2020
dc.identifier.urihttps://rep.bsmu.by/handle/BSMU/29677
dc.descriptionNesterkina, M. V. Protective effect of terpenoids and their derivatives on alcohol with-drawal syndrome / M. V. Nesterkina, I. A. Kravchenko // Физико-химическая биология как основа современной медицины : тез. докл. участников Респ. конф. с междунар. участием, посвящ. 80-летию со дня рождения Т. С. Морозкиной, Минск, 29 мая 2020 г. / под ред. А. Д. Тагановича, В. В. Хрусталёва, Т. А. Хрусталёвой. – Минск : БГМУ, 2020. – С. 120-121.ru_RU
dc.description.abstractBackground. At the core of alcohol withdrawal syndrome is the existence of spontaneous behavioral disturbances that are produced by alcohol removal and suppressed by alcohol replacement. At the molecular level, alcohol has been reported to enhance GABA-activated currents in several cell types expressing different combinations of GABA(A) receptor subunits. Additionally, alcohol is able to influence the other pharmacological targets such as glycine, NMDA and serotonin receptors. At the same time, recent studies have reported that cyclic monoterpenes such as menthol, carvacrol and others have actions within the CNS and act as potent positive allosteric modulators of GABA(A) receptors whereas some terpenes are also antagonists of cortical glycine and GABA(A) receptors. Thus, investigation of terpenoids along with their derivatives containing GABA and glycine residues is an expedient approach for symptoms relief caused by alcohol abuse.ru_RU
dc.language.isoenru_RU
dc.publisherБГМУru_RU
dc.titleProtective effect of terpenoids and their derivatives on alcohol with-drawal syndromeru_RU
dc.typeArticleru_RU


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