Микроскопические изменения в ткани легких и сердца крыс с индуцированной монокроталином легочной гипертензией

Abstract

We used the monocrotaline (MCT) model of pulmonary hypertension which clearly shows the relationship of endothelial dysfunction with impaired regulation of vascular tone. The aim of our work was to examine the model of pulmonary hypertension pathological changes in the lungs and heart of experimental animals. Histological examination on the model revealed persistent pulmonary hypertension remodeling of small and medium-sized pulmonary arterioles, hypertrophy and remodeling of the right ventricle. No signs of cell proliferation in the wall of arterioles lung homogenization their walls, elimination of cells that developed right ventricular failure indicates an irreversible stage of pulmonary hypertension. Thus, for the study of earlier stages of pulmonary hypertension expedient introduction monocrotaline least 2 months.