Ранний ревматоидный артрит и метаболический синдром: клинико-лабораторные особенности течения заболевания у женщин репродуктивного возраста

Abstract

Mechanisms of metabolic syndrome (MS) on the formation and course of the disease in rheumatoid arthritis (RA) remain poorly studied. Several observations show that the patients with RA and MS have higher activity of the disease and low functional status.We compared the disease activity and functional status in 43 women in age from 18 to 55 years, with disease duration of 1 year with early rheumatoid arthritis (ePA) and MS with 35 matched women without MS, not previously treated with disease modifying antirheumatic drugs. We found that the course of RA among the women with MS is characterized by higher process activity and more pronounced decrease in the functional capacity of the patientsFurthermore, the indicators of laboratory activity in the study group were higher compared to patients with eRA and without MS. Thus, our data indicate the need ofcorrection of MS in reproductive age women with RA not only to reduce the risk of cardiovascular complications, but also to reduce the severity of disease activity and functional impairment of the joints.