Полиморфизм гена MTHFR в контексте дименсиональной модели шизофрении

Abstract

Clinical polymorphism of schizophrenia, defined by Liddle in three classic psychopathological dimensions (psychotic symptoms, disorganization, negative symptoms) is based on factor analysis strategy and casts doubt on the idea of common nature of disease's classical symptoms within a single specific process. The search for biological determinants (endophenotypes, risk alleles) of psychopathological dimensions of schizophrenia represents an actual task, nevertheless the system of gene expression regulation (DNA methylation) is still underinvestigated in this aspect. In this article C677T polymorphism of MTHFR gene — the key enzyme for methionine synthesis - has been studied for the association with psychopathological dimensions of schizophrenia.