Изменение оксидантно-антиоксидантного статуса легких новорожденных морских свинок в условиях гипероксии под влиянием липосом, содержащих альфа-токоферол

Abstract

The aim of the present research was to study the influence of aerosolized liposomes containing а-tocopherol on the production of reactive oxygen species (ROS), activity of antioxidant enzymes and content of lipid and protein peroxidation products in lungs of newborn guinea pigs exposed to prolonged hyperoxia. Inhalations of liposomes with а-tocopherol in hyperoxia-exposed animals cause the level of Schiff bases and protein carbonyls in bronchoalveolar lavage fluid (BALF) to decrease, and the activity of glutathione peroxidase to enhance. The intensity of ROS production by BALF cells in response to stimuli increases and attains control values (latex) and even exceeds them (lipopolysaccharide), probably, due to the immunomodulatory effect of а-tocopherol.