Analysis of the interactions between adiponectin hormone and T-cadherin with bioinformatics methods

Abstract

Interaction between adiponectin and T-cadherin provides beneficial cardioprotective and regenerative effects on the cardiovascular system [1–4]. Ad-iponectin accumulates in the heart, endothelium, and skeletal muscles through interaction with T-cadherin [3]. T-cadherin specifically binds with the hexameric and high-molecular form of adiponectin. However, the details of ligand-receptor interaction between adiponectin and T-cadherin remains poorly characterized [5]. The complex of T-cadherin and adiponectin hexamer is still not crystallized and its structure is unknown.