Reduction of lidocaine chronic toxicity with acupuncture in experiment

Abstract

Aim of examination was to study the possibility of the toxicity reducing of the local anesthetic 2% lidocaine hydrochloride during its frequent repeated injections in the maxillofacial region in the experiment with acupuncture. The experiment was performed on two series of white laboratory mice used to determine the toxicity of chemicals, the standardization of preparations, on 33 adult male. All experimental animals were divided into two series which were injected every 3-4 days with 2% lidocaine hydrochloride in dose of 50 mg/kg of body weight in the submandibular region. The first series consisted of 16 animals and served as a control. The second series consisted of 17 animals who had previously received a course of electroacupuncture device on the back paw of the animals according to our scheme of Su-Jok therapy. We collected the parenchymal organs of killed and taken out of the experiment animals for pathomorphological study at each stage of the experiment. After having analyzed the results of experimental examinations we conclude that acupuncture as a prophylactic tretment can significantly reduce the phenomenon of chronic toxicity after repeated injection of lidocaine.