Влияние антимикробных пептидов медицинской пиявки Hirudo medicinalis на функциональную активность нейтрофилов
Influence of antimicrobial peptides of the medicinal leech Hirudo medicinalic on neutrophil functional activity;
Role of the biomarkers in diagnostics of chronic alcohol intoxication
Abstract
Рассмотрены особенности действия новых антимикробных пептидов
(АМП) медицинской пиявки на основные функциональные ответы нейтрофилов.
Среди исследуемых АМП RWRVCFLCRRKKV (536_1) и FRIMRILRVLK (3967_1)
обладали наибольшей способностью активировать респираторный взрыв
нейтрофилов и усиливать дегрануляцию нейтрофилов, регистрируемую по
экзоцитозу миелопероксидазы и лактоферрина. The features of the action of new antimicrobial peptides (AMPs) of the medicinal
leech on the main functional responses of neutrophils are considered. Among the
studied AMPs RWRVCFLCRRKKV (536_1) and FRIMRILRVLK (3967_1) had the
greatest ability to activate the respiratory burst of neutrophils and enhance neutrophil
degranulation, recorded by exocytosis of myeloperoxidase and lactoferrin. In the article, there are discussed the modern possibilities of laboratory
diagnostics of alcohol abuse. There is given the characteristics of traditional indirect
biomarkers with a narrow time window of detection, the level of which can increase in various pathological processes; direct biomarkers that react only to the intake of
ethanol; a number of relatively new "candidates" for biomarkers or components of
biomarker panels. Among all the used biomarkers, the most promising is the
determination of phosphatidylethanol due to its high diagnostic sensitivity and
specificity, as well as the ability to be included in the components of cell membranes,
changing their structural and functional properties. In the article, there are discussed the modern possibilities of laboratory
diagnostics of alcohol abuse. There is given the characteristics of traditional indirect
biomarkers with a narrow time window of detection, the level of which can increase in various pathological processes; direct biomarkers that react only to the intake of
ethanol; a number of relatively new "candidates" for biomarkers or components of
biomarker panels. Among all the used biomarkers, the most promising is the
determination of phosphatidylethanol due to its high diagnostic sensitivity and
specificity, as well as the ability to be included in the components of cell membranes,
changing their structural and functional properties.
Description
Влияние антимикробных пептидов медицинской пиявки Hirudo medicinalis на функциональную активность нейтрофилов [Электронный ресурс] / И. В. Горудко [и др.] // Современные проблемы медицинской биохимии : сб. статей участников Междунар. науч.-практ. конф, посвящ. 85-летию проф. В.К. Кухты, Минск, 25 янв. 2022 г. / под ред. А. Д. Тагановича, Н. Н. Ковганко, В. В. Хрусталева. – Минск, 2022. – C. 56 – 61.
